Objective : The purpose of this paper is to report the effect of three different herb medication based on Shanghanlun(傷寒論) six differential diagnostic system.

Methods : According to six differential diagnostic system based on Shanghanlun provisions, they were diagnosed with Taiyang-byung(大陽病), Yangmyung-byung(陽明病), Gwoleum-byung(厥陰病). They took different herb medications more than 6weeks according to their diagnosis. This paper evaluated the results of treatment by pregnancy test result with improvement of symptoms.

Results : The symptoms of three patients were improved and became pregnant.

Conclusions : This case study suggests that herb medication based on Shanghanlun(傷寒論) six differential diagnostic system have effectiveness on unexplained infertility. And we need to have a diversified and new perspectives in women's position about pregnancy with this system.

KeyWords : infertility, herbal medicine, Shanghanlun(傷寒論), unexplained infertility, six differential diagnostic system (辨病診斷體系)