Review Article

허혈성 심질환에 활용된 四逆湯의 최신 연구 동향

Recent Research Trends of Sayeok-tang Used in Ischemic Heart Disease

2021 Vol. 13 No. 1
장일웅1 · 홍준영2 · 이숭인3

목포 청연한방병원1
동신대학교 한의과대학3
Jang Il-Woong1 · Hong Jun-yeong2 · Lee Soong-in3*
1. Mokpo Chung Yeon Korean Medicine Hospital1
2. On You Korean Medicine Clinic2
3. College of Korean Medicine, Dongshin University3*


Purpose : Sayeok-tang (Sini decoction, SND) is a cold-dispelling formula used for cold deficiency syndrome and is composed of Aconiti Lateralis Radix Preperata, Zingiberis Rhizoma, and Glycyrrhizae Radix et Rhizoma. It is used for diseases such as myocardial infarction, heart failure, acute and chronic gastroenteritis, and gastric effusion. This study proposes the possibility of expansion of basic research and clinical applications for ischemic heart disease (IHD) through systematic analysis of domestic and foreign studies on SND.

Methods : We collected studies within the last 10 years on the use of SND in IHD and excluded those lacking relevance. Selected studies were classified by research method and the main themes of the studies were analyzed for each classification.

Result : Out of 15 studies, there were 5 animal studies, 8 metabolite analyses in animals, 1 in vitro study, and 1 systematic review. Our review suggests that SND may be used as an adjuvant to nitroglycerin and percutaneous transluminal coronary angioplasty, and may improve symptoms and quality of life of patients with IHD. Myocardial protective effects through antioxidant, anti-inflammatory, anti-apoptotic, and anti-hypertensive actions were confirmed through these studies. Effects on carbohydrate, protein, and lipid metabolism were also reported.

Conclusions : This study suggests that SND has potential as a treatment for IHD.

Key words : Sayeok-tang, Sini decoction, SND, Aconiti Lateralis Radix Preperata, ischemic heart disease, herbal medicine, Shanghanlun, myocardial infarction