Original Article

D-Galactosamine으로 유발된 흰쥐의 간손상에 대한 치자와 두시 추출액이 미치는 영향

Effect of the Gardenia jsaminodes and Glycine max on Hepatotoxicity of D-Galactosamine in Rats

2012 Vol. 4 No. 1
동신대학교 한의과대학 해부학교실†, 동신대학교 한의과대학 본초학교실*
Jeong-Sang Kim†․Jong-Kil Jeong*
Dept. of Anatomy, College of Oriental Medicine, Dong-Shin University†
Dept. of Herbology, College of Oriental Medicine, Dong-Shin university


Aim : To investigate the hepatotective effect of Gardenia jsaminodes and Glycine max  aqueous extract against D-galactosamine (d-GalN, 300㎎/㎏ body weight) was administered to the male Sprague Dawley (SD) rats.

Materials and Methods : The study was carried out on male SD rats (age matched, weight 250±10 g). Experimental groups divided four: Normal group (Nor) was administered saline, Control (Con) group was administered saline after d-GalN treatment. Experimental group (Exp) was administered Gardenia jsaminodes (200 mg/kg; Ga group), Glycine max (700 mg/kg; Gl group), and Gardenia jsaminodes+Glycine max (200 mg/kg+700 mg/kg, GG group) during 14 days(n=5).

Results : d-GalN administration induced hepatotoxicity in rats which was manifested by increased levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase but decreased total cholesterol and triglyceride. Treatment with Gardenia jsaminodes extract significantly protected the liver in d-GalN administered rats.

Conclusion :  Gardenia jsaminodes  aqueous extract and  Gardenia jsaminodes+Glycine max  extract possesses hepatoprotective potential, thus validating its use in alleviating toxic effects of d-GalN.

KeyWords : D-galactosamine, Gardenia jsaminodes, Glycine max, hepatotective



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